FISH (FLUORESCENCE (in situ) HYBRIDIZATION)

Components
Genetic Disease (FISH)*
*Probes available: SRY gene, Prader-Willi syndrome, Angelman syndrome, DiGeorge syndrome/Velocardiofacial syndrome, Williams syndrome, Steroid sulfatase (STS) probe, Kallman's syndrome, Miller-Dieker syndrome, Smith-Magenis syndrome, Wolf-Hirschhorn syndrome, Cri-du-Chat syndrome. Please specify genetic disorder suspected. Please call Client Service for availabilityof other probes.
Hematologic FISH probes:
Acute Myeloid Leukemia Panal; Plasma Cell Myeloma Complete Panel w/ IGH reflex; Chronic Lymphocytic Leukemia Panel; MDS Panel; Acute Lymphoblastic Leukemia Panel, Pediatric; Acute Lymphoblastic Leukemia Panel, Adult (CDKN2A, BCR/ABL1, KMT2A); MALT Lymphoma Study (Chromosome 3, MALT1); Marginal Zone Lymphoma Panel (BCL6, 7p/7q, CEP12); BCR/ABL1 [t(9;22)]; PML/RARA [t(15/17)]; IGH/BCL2 [t(14:18)]; CCND1 (BCL1/IGH [t(11;14)]; High Grade Lymphoma Panel (MYC, IGH/BCL2, BCL6); RUNX1T1 [t(8;21)]; CBFB/MYH11 (inv(16) & t(16;16)]; MYC/IGH [t(8;14)]; ALK (2p23); BCL6 (3q27); Eosinophilia Panel (PDGFRA, PDGFRB, FGFR1); KMT2A (MLL, 11q23); T-cell alpha/delta receptor. Please specify Hematologic disorder suspected. Please call Client Service for availability of other probes.

Specimen Required
Draw blood in a green sodium heparin tube. Send 5.0 mL whole blood (3.0 mL minimum) room temperature. Completed Warde Medical Laboratory Cytogenetics Test Requisition Genetic Disorder required. Please state FISH probe required on requisition.

Alternate Specimen
Bone Marrow

Rejection Criteria
Lithium heparin samples

Methodology
Cultures, staining and other techniques when required

Stability
Room Temperature: 72 hours; Refrigerated: 72 hours; Frozen: Unacceptable

Reference Range
Interpretive report

Performed
Monday-Saturday

Turnaround Time4-10 days
Test CodeFISH
CPT-4 Code (s)
Varies depending on what was performed
LOINC Codes
Not available at this time

Warde
Medical
Laboratory