METANEPHRINES, URINE - RANDOM

Specimen Required
Collect random urine. Add 1-2 drops 6N HCl to a 10 mL urine aliquot within 4 hours on collection. Mix well, ensure pH is between 1-3, and send urine (5.0 mL minimum) refrigerated in a screw-capped plastic urine container.
Note: Medications that may interfere with metanephrine include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, carbidopa-levopa (Sinemet), clonidine, dexamethasone, diuretics (in doses sufficient to deplete sodium), methyldopa (aldomet), MAO inhibitors, nose drops, propafenone (Rythmol), tricyclic antidepressants, and vasodilators.

Alternate Specimen
Collect random urine, mix well and send 10.0 mL urine (5.0 mL minimum) refrigerated in a screw-capped plastic urine container.

Rejection Criteria
Samples with pH <1

Methodology
High Performance Liquid Chromatography

Stability
With preservative: Room temperature: 9 days; Refrigerated: 9 days; Frozen: 30 days
Without preservative: Room temperature: 9 days; Refrigerated: 9 days; Frozen: 30 days

Reference Range
By report

Performed
Setup: Monday, Wednesday, Friday
Reported; 2-4 days

Turnaround Time4-6 days
Test CodeUMETR
CPT-4 Code (s)
83835, 82570
LOINC Codes
Creatinine   2161-8  
Metanephrine   13771-1  
Normetanephrine   13783-6  

Warde
Medical
Laboratory