PROCALCITONIN

Components
The same specimen type (serum, plasma) should be used throughout the patient's clinical course.

Specimen Required
Draw blood in a SST. Allow sample to clot 15-20 minutes, centrifuge and separate serum from cells within 2 hours of collection. Send 2.0 mL serum (0.3 mL minimum) refrigerated in a screw-capped plastic vial.

Alternate Specimen
Serum: Red-top
Plasma: EDTA or sodium or lithium heparin

Rejection Criteria
Plasma: Citrate

Methodology
Immunoassay

Stability
Room Temperature: 24 hours; Refrigerated: 5 days; Frozen: 1 month

Reference Range
<0.07 ng/mL
Interpretive Data: A Correction has been applied to optimize cutoffs established for the BRAHMS PCT sensitive KRYPTOR assay.
Procalcitonin >2.00 ng/mL; Procalcitonin levels above 2.00 ng/mL on the first day of ICU admission represent a high risk for progression to severe sepsis and/or septic shock.
Procalcitonin <0.50 ng/mL: Procalcitonin levels below 0.50 ng/mL on the first day of ICU admission represent a low risk for progression to severe sepsis and/or septic shock.
If the procalcitonin measurement is performed shortly after the systemic infection process has started (usually less than 6 hours), these values may still be low. As various non-infectious conditions are known to induce procalcitonin as well, procalcitonin levels between 0.50 ng/mL and 2.00 ng/mL should be reviewed carefully to take into account the specific clinical background and conditions(s) of the individual patient.

Performed
Sunday-Saturday

Turnaround Time2-3 days
Test CodePRCAL
CPT-4 Code (s)
84145
LOINC Codes
33959-8

Warde
Medical
Laboratory