SERTRALINE

Specimen Required
Draw blood in a plain red-top tube. Centrifuge, separate serum from cells within 2 hours and send 1.0 mL serum (0.5 mL minimum) refrigerate in a screw-capped plastic vial.

Alternate Specimen
Plasma: EDTA

Rejection Criteria
SST or PST (Polymer gel separation tube), whole blood, citrated plasma or ACD plasma

Methodology
Quantitative Liquid Chromatography/Tandem Mass Spectrometry

Stability
Room Temperature: 5 days; Refrigerated: 14 days; Frozen: 6 months

Reference Range
Toxic:   >300 ng/mL  
Sertraline doses ranging from 50-200 mg/d produce serum concentration ranging from 30-200 ng/mL. Dosing above 200 mg/d is associated with increased adverse effects and decreased efficacy. Adverse effects may include dry mouth, headache, dizziness, somnolence, nausea and diarrhea.

Performed
Tuesday, Friday

Turnaround Time4-6 days
Test CodeSERT
CPT-4 Code (s)
80332 (G0480)
LOINC Codes
6906-2

Warde
Medical
Laboratory