TRICYCLIC ANTIDEPRESSANT PANEL, QUANTITATIVE

Test Documentation
Components
Includes: Amitryptyline, Desipramine, Doxepin, Imipramine, Nordoxepin and Nortriptyline. For therapeutic drug monitoring please order test for individual drug.

Specimen Required
Draw blood in a plain red-top tube. Centrifuge, separate and send 1.0 mL (0.5 mL minimum) refrigerated in a screw-capped plastic vial.

Rejection Criteria
SST

Methodology
High Performance Liquid Chromatography

Stability
Room Temperature: 48 hours; Refrigerated: 14 days; Frozen: 14 days

Reference Range
Drug   Reference Range   Toxic Level  
Amitriptyline   NA   >500 ng/mL  
Nortriptyline   50-140 ng/mL   >500 ng/mL  
Amit & Nort   90-250 ng/mL   >500 ng/mL  
Imipramine   NA   NA  
Desipramine   150-300 ng/mL   >500 ng/mL  
Imip & Desi   150-300 ng/mL   >500 ng/mL  
Doxepin   NA   >500 ng/mL  
Nordoxepin   NA   >500 ng/mL  
Doxepin & Nordoxepin   100-200 ng/mL   >500 ng/mL  

Performed
Monday-Friday

Turnaround Time2 days
Test CodeTADSP
CPT-4 Code (s)
80337 (G0480)
LOINC Codes
Amitriptyline   3333-2  
Nortriptyline   3872-9  
Desipramine   3531-1  
Imipramine   6946-8  

Warde
Medical
Laboratory