QUAD1 – “QUAD Screen” replaced by QUADS – “Maternal Serum Screen Quad”

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Inactivated/Replace Test

Effective Date

08/24/2026

Included in Report

WML Test Directory Update | August 2026

Replacement Test

Maternal Serum Screen Quad

Inactivated Test Details

Mnemonic

QUAD1

Ordering Code

3000356

CPT-4 Codes(s)

81511 (or 82105, 82677, 84702, 86336)

Replacement Test Details

Mnemonic

QUADS

Ordering Code

3600606

CPT-4 Codes(s)

81511

Turnaround Time
4 - 6 days
Performed
Sunday - Saturday
Legacy Code
QUADS
Example Report
Download

Specimen Information

Patient Preparation

Collect sample between 14 weeks 0 days and 24 weeks 6 days gestation. Send completed Quad Screen Information sheet with each specimen.

Collect

Red top

Specimen Preparation

Centrifuge, separate serum from cells within 2 hours of collection and send 3.0 mL serum in a screw capped plastic vial.

Alternate Specimen

Serum separator tube (SST)

Minimum Volume

1.0 mL

Transport Temperature

Refrigerated

Rejection Criteria

Plasma. Hemolyzed specimens.

Stability

Room temperature: 72 hours
Refrigerated: 14 days
Frozen: 1 year (Avoid repeated freeze/thaw cycles.)

Methodology

Qualitative Chemiluminescent Immunoassay (CLIA)
more

Reference Range

See report
more

Performing Laboratory

ARUP Reference Laboratory
more

New York DOH Approval Status

Yes
more

Interface Map for QUADS

Test Name Ordering Code Result Code Component Name LOINC Code AOE Prompt Units
Maternal Serum Screen Quad3600606
3600607Client Provided Maternal Date of Birth21112-8Yes
3600608Client Provided Maternal Weight29463-7Yes
3600609Client Provided Patient Weight UnitsYes
3600611Client Provided Due Date11778-8Yes
3600612Client Provided Dating Method21299-3Yes
3600613Client Provided Last Menstrual Period8665-2Yes
3600614Client Provided Number of Fetuses55281-0Yes
3600616Client Provided Race of Mother21484-1Yes
3600617Client Provided Diabetic Status33248-6Yes
3600618Client Provided Current Smoking64234-8Yes
3600619Client Provided Valproic/Carbamazepine19009-0Yes
3600621Client Provided Previous Trisomy Preg68328-4Yes
3600622Client Provided Family History of NTD8670-2Yes
3600623Client Provided In Vitro Fertilization47224-1Yes
3600624Donor Egg Age at HarvestYes
3600626Client Provided Repeat Specimen8251-1Yes
3600627Patient's AFP1834-1No
3600628MoM for AFP20450-3No
3600629Patient's uE32250-9No
3600631MoM for uE320466-9No
3600632Patient's hCG, 2nd Trimester19080-1No
3600633hCG MoM, 2nd Trimester20465-1No
3600634Patient's DIA23883-2No
3600636MoM for DIA35738-4No
3600637Maternal Screen Interpretation49586-1No
3600638Maternal Age at Delivery21612-7No
3600639Maternal Weight29463-7No
3600641Estimated Due Date11778-8No
3600642Gestational Age Calculated at Collection18185-9No
3600643Dating21299-3No
3600644Number of Fetuses11878-6No
3600646Maternal Race21484-1No
3600647Maternal Diabetes at Conception44877-9No
3600648Smoking64234-8No
3600649Family Hx Neural Tube Defect8670-2No
3600651Family History of Aneuploidy32435-0No
3600652Specimen19151-0No
3600653EER Maternal Serum, Quad11526-1No

The CPT codes provided are for general informational purposes only and are based on an interpretation of AMA guidance. It is the sole responsibility of the billing party to determine CPT codes. Any questions regarding coding should be directed to the paying party.

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