Test Details

Mnemonic

ALDR

Ordering Code

1003990

CPT-4 Code(s)

82088, 84244

Specimen Information

Patient Preparation

Angiotensin Converting Enzyme (ACE) Inhibitors should be avoided, if possible, for at least 48 hours prior to collection. Spironlactone (Aldactone) should be discontinued 4 - 6 weeks prior to testing. Patient should be on a normal sodium diet.

Collect

Aldosterone: Serum separator tube (SST) and
Direct Renin: Lavender EDTA

Specimen Preparation

Centrifuge in a non refrigerated centrifuge, separate serum from cells and send 1.0 mL serum in a screw capped plastic vial. Label this tube "Serum-Aldosterone".

Centrifuge, separate plasma from cells and send 1.5 mL plasma in a screw capped plastic vial. CRITICAL FROZEN. Label this tube "Frozen Plasma-Renin". Also, please match sample requirement on label to correct sample type.

Alternate Specimen

Aldosterone:
Serum: Red top
Direct Renin: No alternate specimen

Transport Temperature

Serum: Refrigerated
Plasma: Frozen

Rejection Criteria

Aldosterone: Plasma: gross hemolysis, gross lipemia

Renin: Hemolysis, grossly lipemic or icteric specimens, non-frozen samples, serum, dark blue
trace element EDTA

Stability

Aldosterone:
Room temperature: Unacceptable
Refrigerated: 5 days
Frozen: 30 days

Renin:
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days

Methodology

Aldosterone: Chemiluminescence
Direct Renin: Chemiluminescence
Ratio: Calculation
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Reference Range

Aldosterone: Upright: ≤39.2 ng/dL
Supine: ≤23.2 ng/dL
Aldosterone/Direct Renin Ratio: 0.1 - 3.7
Renin: 3.1 - 57.1 pg/mL
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Performing Laboratory

Warde Medical Laboratory
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