Test Details

Mnemonic

CADEP

Ordering Code

3687700

CPT-4 Code(s)

82300 x 2, 82232

Specimen Information

Patient Preparation

To avoid contamination, please collect specimens at the beginning of work shift. Blood and urine should be collected the same day.

Urine: diet, medication and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals and non-essential over-the-counter medications (upon the advice of their physician). High concentrations of iodine may interfere with elemental testing. Collection of urine specimens from patients receiving iodinated or gadolinium-based contrast media should be avoided for a minimum of 72 hours post-exposure. Collection from patients with impaired kidney function should be avoided for a minimum of 72 hours post-exposure. Collection from patients with impaired kidney function should be avoided for a minimum of 14 days post contrast media exposure.

Collect

Dark blue EDTA and minimum 40 mL urine

Specimen Preparation

Cadmium, Blood: Draw blood in a dark blue EDTA. Send 7.0 mL whole blood refrigerated in original collection tube or a blue-capped ARUP metal-free screw capped plastic vial.

Urine: Collect 40.0 mL random urine

Cadmium, Urine: Send 7 mL urine from the random collection. Send refrigerated in a blue-capped ARUP metal-free screw capped plastic vial labeled "Cadmium".

Creatinine, Urine: Send 5.0 mL urine from the random collection refrigerated in an screw capped plastic vial labeled "creatinine".

B-2-Microglobulin, Urine: Send 4.0 mL urine from the random collection, adjusted to pH 6 - 8 using 1M HCl or 5% NaOH, frozen in an screw capped plastic vial, labeled B2M. Freeze within one hour of collection.

Minimum Volume

0.5 mL blood/0.5 mL for each urine

Rejection Criteria

Blood - Specimens collected in tubes other than Dark Blue EDTA
Heparinized specimens
Clotted specimens
Cadmium, Urine - Specimens not in blue-capped ARUP metal-free vials
Specimens containing blood or fecal material
Specimens collected within 72 hours after administration of iodinated or gadolinium-based contrast media

Stability

Cadmium, Blood: If the sample is drawn and stored in the appropriate container, the trace element values do not change with time.

Cadmium, Urine:
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 1 year

Creatinine, Urine:
Room temperature: 24 hours
Refrigerated: 4 days
Frozen: 60 days

Beta-2-Microglobulin, Urine:
Room temperature: 8 hours
Refrigerated: 2 days
Frozen: 60 days

Methodology

Cadmium, Urine & Blood: Inductively Coupled Plasma/Mass Spectrometry
Urine: Chemiluminescent Immunoassay
Creatinine, Urine: Spectrophotometry
B-2-Microglobulin, Urine: Chemiluminescent Immunoassay
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Reference Range

Cadmium, Urine - per volume: 0.0 - 1.0 ug/L
Cadmium, Urine - per 24h: 0.0 - 3.2 ug/d
Cadmium, Urine - ratio to CRT 0.0 - 3.2 ug/g CRT
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Performing Laboratory

ARUP Reference Laboratory
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New York DOH Approval Status

Yes
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DUE TO A NATIONWIDE SHORTAGE OF DARK BLUE EDTA TRACE ELEMENT TUBES, WARDE LAB IS TEMPORARILY ACCEPTING LAVENDER EDTA TUBES.