Test Details

Mnemonic

UMET

Ordering Code

1007094

CPT-4 Code(s)

83835, 82570

Specimen Information

Patient Preparation

Medications that may interfere with metanephrine include amphetamines and amphetamine - like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, carbidopa - levodopa (Sinemet), clonidine, dexamethasone, diuretics (in doses sufficient to deplete sodium), methyldopa (Aldomet), MAO inhibitors, nose drops, propafenone (Rythmol), trycyclic antidepressants, and vasodilators. Patient should consult their physician before discontinuing any medication.

Collect

24 hour urine. The bladder must be emptied at the time the collection is to begin and this urine discarded. Thereafter all urine must be collected until the end of the scheduled time. Collect urine with 6N HCl at start of collection to maintain pH between 1 and 3. Refrigerate urine during collection (critical). Mix the collection well before removing aliquot.

Specimen Preparation

Send 25 mL acidified urine in a screw capped plastic urine container. Record total volume on test requisition and specimen label.

Alternate Specimen

Alternate method of 24 hour collection with preservative: Refrigerate urine during collection and add 25.0 mL of 6NHCl to the entire collection within 24 hours of collection completion. Mix collection well, and check pH to ensure pH is between 1 and 3. Send a 25.0 mL urine aliquot in a screw capped plastic urine container. Record total volume on container label.

Alternate method of 24 hour collection without preservative: Refrigerate urine during collection. Mix well and send 25.0 mL urine in a screw capped plastic urine container. Record total volume on container label.

Minimum Volume

10.0 mL

Transport Temperature

Refrigerated

Rejection Criteria

Samples with pH <1

Stability

With preservative:
Room temperature: 9 days
Refrigerated: 9 days
Frozen: 30 days

Preservative must be added before sample is submitted for testing.

Methodology

High Performance Liquid Chromatography
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Reference Range

Metanephrine:
Age Range
0 - 3 months 6 - 37 mcg/day
4 - 6 months 6 - 42 mcg/day
7 - 9 months 12 - 41 mcg/day
10 - 12 months 9 - 101 mcg/day
1 - 2 years 7 - 52 mcg/day
3 - 6 years 11 - 99 mcg/day
7 - 10 years 54 - 138 mcg/day
11 - 16 years 39 - 242 mcg/day
≥17 yrs 52 - 341 mcg/day

Normetanephrine:
Age Range
0 - 3 months 47 - 156 mcg/day
4 - 6 months 31 - 111 mcg/day
7 - 9 months 42 - 109 mcg/day
10 - 12 months 23 - 103 mcg/day
1 - 2 years 32 - 118 mcg/day
3 - 6 years 50 - 111 mcg/day
7 - 10 years 47 - 176 mcg/day
11 - 16 years 53 - 290 mcg/day
≥17 years 88 - 444 mcg/day

Total Metanephrines:
Age Range
0 - 3 months 53 - 193 mcg/day
4 - 6 months 37 - 153 mcg/day
7 - 9 months 54 - 150 mcg/day
10 - 12 months 32 - 204 mcg/day
1 - 2 years 39 - 170 mcg/day
3 - 6 years 61 - 210 mcg/day
7 - 10 years 101 - 314 mcg/day
11 - 16 years 92 - 532 mcg/day
≥17 years 140 - 785 mcg/day

Creatinine:
Male: 1.0 - 2.0 g/24 hrs
Female: 0.8 - 1.8 g/24 hrs
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Performing Laboratory

Warde Medical Laboratory
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New York DOH Approval Status

Yes
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