Test Details

Mnemonic

MLH1

Ordering Code

3624180

CPT-4 Code(s)

81288, 88381

Specimen Information

Collect

Tumor tissue

Specimen Preparation

Send formalin fixed paraffin embedded tissue block or 5 unstained 5 micron slides in a tissue transport kit. Include surgical pathology report.

If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of
the following: an order comment indicating that the ARUP pathologist should choose the
specimen most appropriate for testing, or individual orders for each sample submitted. A
Pathologist Block Selection Fee will be added to orders that utilize the first option. If multiple
specimens are sent to ARUP without a request for pathologist block/slide selection or individual
orders, they will be held until clarification is provided.

Alternate Specimen

DNA extracted by CLIA certified lab with corresponding client-circled H&E slide. Call Client Services for specimen requirements.

Minimum Volume

3 slides (if using)

Transport Temperature

Room temperature

Rejection Criteria

Specimens fixed in alcohol or heavy metal fixative, decalcified specimens, less than 25% tumor, DNA extracted by a non-CLIA lab, DNA extracted without a corresponding-circled H & E slide

Stability

Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable

Methodology

Real-Time Polymerase Chain Reaction/Fluorescence Resonance Energy Transfer
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Reference Range

See report
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Performing Laboratory

ARUP Reference Laboratory
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New York DOH Approval Status

Yes
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