January 2026 WML Test Directory Update

Update to reference range

Reference Range: 5.0 – 16.0 μg/dL

Update to specimen requirements

Specimen Preparation: Send 2.5 Cerebrospinal fluid (CSF) in a screw capped polypropylene vial.

Minimum Volume: 1.0 mL

Update to methodology and reference range

Methodology: Turbidimetric Measurement of Liposome Lysis

Reference Range: > or = 39 U/mL

Update to methodology and reference range

Methodology: Turbidimetric Measurement of Liposome Lysis

Reference Range: > or = 56 U/mL

Update to methodology and reference range

Methodology: Turbidimetric Measurement of Liposome Lysis

Reference Range: > or = 58 U/mL

Update to methodology and reference range

Methodology: Turbidimetric Measurement of Liposome Lysis

Reference Range: > or = 57 U/mL

Update to methodology and reference range

Methodology: Turbidimetric Measurement of Liposome Lysis

Reference Range: > or = 60 U/mL

Update to specimen requirements, alternate specimen, rejection criteria, stability, performed days, and turnaround time

Minimum Volume: Bone Marrow: 1.0 mL; Whole blood: 3.0 mL

Alternate Specimen:

Bone marrow: Lavender EDTA, ACD solution A or B, sodium heparin (3.0 mL)
Whole blood: ACD solution A or B, sodium heparin

Rejection Criteria: Clotted sample frozen sample

Stability:

Room temperature: 5 days
Refrigerated: 5 days
Frozen: Unacceptable

Performed Days: Monday – Saturday

Turnaround Time: 7 – 9 days

Update to specimen requirements

Specimen Preparation: Send 2.0 mL urine in a screw-capped plastic urine container.

Update to specimen requirements, stability, rejection criteria, methodology and reference range

Collect: Dark blue K2EDTA and minimum 40 mL urine

Specimen Preparation:

Cadmium, Blood: Draw blood in a dark blue K2EDTA. Send 3.0 mL whole blood in original collection tube or a blue-capped ARUP metal-free screw capped plastic vial.

Urine: Collect 40.0 mL random urine

Cadmium, Urine: Send 7.0 mL urine from original urine collection in a blue-capped ARUP metal-free screw capped plastic vial labeled “Cadmium”.

Creatinine, Urine: Send 2.0 mL urine from original urine collection in an screw capped plastic vial labeled “creatinine”.

B-2-Microglobulin, Urine: Send 3.0 mL urine aliquot from original urine collection, adjusted to pH 6 – 8 using 1M HCl or 5% NaOH, frozen in an screw capped plastic vial, labeled B2M. Freeze within one hour of collection.

Transport Temperature:

Blood: Refrigerated
Urine for Beta-2-Microglobulin: Frozen
Urine for Cadmium: Refrigerated
Urine for Creatinine: Refrigerated

Rejection Criteria:

Blood – Specimens collected in tubes other than Dark Blue K2EDTA or Royal Blue Sodium heparin.
Clotted specimens
Cadmium, Urine – Specimens not in blue-capped ARUP metal-free vials
Specimens containing blood or fecal material
Specimens collected within 72 hours after administration of iodinated or gadolinium-based contrast media

Stability:

Cadmium, Blood:
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable

Cadmium, Urine:
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 1 year

Creatinine, Urine:
Room temperature: 24 hours
Refrigerated: 30 days
Frozen: 6 months

Beta-2-Microglobulin, Urine:
Room temperature: 8 hours
Refrigerated: 2 days
Frozen: 60 days

Methodology:

Quantitative Inductively Coupled Plasma – Mass
Spectrometry/Spectrophotometry/Chemiluminescent Immunoassay

Reference Range:

Beta-2-Microglobulin, ratio to CRT: 0-300 μg/g CRT
Beta-2-Microglobulin, Urine: 0-300 μg/L
Cadmium, Urine – per volume: <= 1.0 μg/L
Cadmium, Urine – ratio to CRT <= 3.0 μg/g CRT
Cadmium, Whole blood: <= 5.0 μg/L

Update to alternate specimen, rejection criteria, stability, and methodology

Alternate Specimen: Plasma: Light blue sodium citrate, lavender EDTA, green sodium or lithium heparin

Rejection Criteria: Hemolyzed or lipemic specimens, room temperature specimens. Specimens containing particulate material or obvious microbial contamination.

Stability:

Room temperature: 24 hours
Refrigerated: 5 days
Frozen: 30 days (avoid repeated freeze/thaw cycles)

Methodology: Qualitative Enzyme Immunoassay (EIA)

Update to specimen requirements, rejection criteria, and reference range

Patient Preparation: Patients are encouraged to discontinue nutritional supplements, vitamins, minerals and non-essential over the counter medication. Abstinence from iodine – containing medications or contrast agents for at least 1 month prior to collecting specimens for elemental testing is recommended.

Rejection Criteria: Acid preserved urine, specimens contaminated with blood or fecal material, urine collected within 48 hours of gadolinium administration (contrast media), specimens received in non-metal free tubes.

Reference Range:

Creatinine, Urine – 24h See report
Nickel, Urine – per 24h <=14.9 μg/d
Nickel, Urine – per volume <= 10.4 μg/L
Nickel, Urine – ratio to CRT <= 9.9 μg/g CRT

Update to specimen requirements and alternate specimen

Patient Preparation: Patient must fast 10 – 12 hours before collection.

Specimen Preparation: Centrifuge, separate serum from cells within 2 hours and send 1.0 mL serum or plasma in a screw capped plastic vial. CRITICAL FROZEN.

Alternate Specimen:

Plasma: Lavender (K2EDTA) or pink (K2EDTA)
Serum: Red top

Update to specimen requirements, rejection criteria, methodology, and reference range

Specimen Preparation: Mix urine well and send 8.0 mL urine in a blue capped ARUP metal-free screw capped plastic vial. Record total volume and collection time interval on transport tube.

Rejection Criteria:

Acid preserved urine.
Urine collected within 48 hours after administration of a gadolinium containing contrast media. Specimen contaminated with blood or fecal material. Specimens transported in non-trace element free transport tube.

Methodology: Quantitative Inductively Coupled Plasma – Mass Spectrometry (ICP-MS)

Reference Range:

Cadmium, Urine – per volume: <= 1.0 μg/L
Cadmium, Urine (24-hour): <= 3.2 μg/d
Cadmium Urine- ratio to CRT: <= 3.2 μg/g CRT
Creatinine (24-hour): See Report

Update to specimen requirements and reference range

Specimen Preparation: Mix well and send 8.0 mL urine in a blue-capped ARUP metal-free screw capped plastic vial. Please contact lab for metal-free screw capped plastic vials. Specimens in other containers will be rejected. Record total volume and collection time interval on test requisition and specimen label.

Reference Range:

Mercury, Urine – per volume: <= 5.0 μg/L
Mercury, Urine – per 24h: <= 20.0 μg/d
Mercury, Urine -ratio to CRT: <= 20.0 μg/g CRT
Creatinine, Urine – per 24h: See report

Update to reference range

Reference Range:

Mercury, Urine – per volume <= 5.0 μg/L
Mercury, Urine – ratio to CRT <= 20.0 μg/gCRT

Update to reference range

Reference Range:

Lead, Urine – per volume: <= 5.0 μg/L
Lead, Urine – per 24h: <= 8.1 μg/d
Lead, Urine – ratio to CRT: <= 5.0 μg/g CRT
Creatinine, Urine – per 24h: See report

Update to reference range

Reference Range:

Lead, Urine – per volume <= 5.0 μg/L
Lead, Urine – ratio to CRT <= 5.0 μg/gCRT