May 2024 WML Test Directory Update

Update to specimen requirements.

Minimum Volume: 0.5 mL

Update to rejection criteria and stability.

Rejection Criteria: Grossly hemolyzed, heat-treated, microbially contaminated or lipemic specimens, plasma

Stability: Room temperature: 8 hours
Refrigerated: 7 days
Frozen: Undetermined 

Update to rejection criteria and stability.

Rejection Criteria: Grossly hemolyzed, heat-treated, microbially contaminated or lipemic specimens, plasma

Stability:

ANA:
Room temperature: 8 hours
Refrigerated 7 days
Frozen: Undetermined

Anti-ds DNA, Anti-SM, Anti-RNP, Anti-SSA, Anti-SSB, Anti-Scl-70, Jo-1 IgG:
Room temperature: 8 hours
Refrigerated: 14 days
Frozen: Undetermined

Update to rejection criteria and stability.

Rejection Criteria: Grossly hemolyzed, heat-treated, microbially contaminated or lipemic specimens, plasma

Stability: Room Temperature: 8 hours
Refrigerated: 48 hours
Frozen: Undetermined

Update to specimen requirements and reference range.

Minimum Volume: 0.5 mL 

Reference Range:

Therapeutic:
Chlordiazepoxide: 100 – 3000 ng/mL
Diazepam: 100 – 1000 ng/mL
Nordiazepam: 100 – 1000 ng/mL
N-Desalkylflurazepam: 30 – 150 ng/mL
Oxazepam: 200 – 500 ng/mL
Lorazepam: 50 – 240 ng/mL
Alprazolam: 7 – 40 ng/mL
Clonazepam: 15 – 60 ng/mL
Temazepam: 50 – 1000 ng/mL

Toxic:
sum of Diazepam + Nordiazepam: >5000 ng/mL
Nordiazepam: >3000 ng/mL
Diazepam: >3000 ng/mL
N-Desalkylflurazepam: >300 ng/mL
Oxazepam: NA
Lorazepam: >300 ng/mL
Alprazolam: >100 ng/mL
Clonazepam: >80 ng/mL
Temazepam: >3000 ng/mL

Update to New York approval.

New York DOH approval Status: Yes

Update to test name and specimen requirements.

Name: Clinical Urine Drug Abuse Screen 3A

Collect: Random urine

Specimen Preparation: Send 30.0 mL urine in a screw capped plastic urine container.
Pediatric: Newborn minimum requires 1.0 mL urine.
All positive screen results are considered presumptive results. 

Minimum Volume: 15.0 mL

Update to specimen requirements and methodology.

Specimen Preparation: Send 30.0 mL urine in a screw capped plastic urine container. Pediatric: Newborn minimum requires 1.0 mL urine. All positive screen results are considered presumptive positives except for amphetamines and PCP, which are confirmed to ensure accuracy of screening result.
This panel is NOT designed to detect low levels of buprenorphine, fentanyl, meperidine, oxycodone or tramadol. See the PNO3A panel if these tests are required. 

Methodology: Liquid Chromatography/Tandem Mass Spectrometry

Update to specimen requirements and methodology.

Specimen Preparation: Send 30.0 mL urine in a screw capped plastic urine container. Newborn minimum requires 1.0 mL urine. All positive screen results are considered presumptive positives except for amphetamines and PCP, which are confirmed to ensure accuracy of screening result. 

Methodology: Enzyme Immunoassay; Gas Chromatography/Mass Spectrometry; Liquid
Chromatography/Tandem Mass Spectrometry 

Update to specimen requirements and methodology.

Specimen Preparation: Send 30.0 mL urine in a screw capped plastic urine container. Pediatric: Newborn minimum requires 1.0 mL urine.

All positive screen results are considered presumptive results except for amphetamines and PCP, which are confirmed to ensure accuracy of screening result.

This panel is NOT designed to detect low levels of buprenorphine, fentanyl, meperidine, oxycodone or tramadol. See the PN03A panel if these tests are required. 

Minimum Volume: 15.0 mL

Methodology: Liquid Chromatography/Tandem Mass Spectrometry

Update to specimen requirements and methodology.

Specimen Preparation: Send 30.0 mL urine in a screw capped plastic urine container. Pediatric: Newborn minimum requires 1.0 mL urine. All positive screen results are considered presumptive results except for amphetamines and PCP, which are confirmed to ensure accuracy of screening result.

This panel is NOT designed to detect low levels of buprenorphine, fentanyl, meperidine, oxycodone or tramadol. See the PN03A panel if these tests are required. 

Minimum Volume: 15.0 mL

Methodology: Liquid Chromatography/Tandem Mass Spectrometry 

Update to specimen requirements, alternate specimen, and stability.

Minimum Volume: 0.5 mL

Alternate Specimen: No alternate specimen listing. 

Stability: Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 14 days

Update to alternate specimen and stability.

Alternate Specimen: No alternate listing.

Stability: Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 14 days

Update to specimen requirements, stability, and reference range.

Specimen Preparation: Send 1.0 mL whole blood refrigerated. CAUTION: The complexity of the clinical state, individual differences in sensitivity to the immunosuppressive and nephrotoxic effects of cyclosporine, the co-administration of other immunosuppressants, the type of transplant and a number of other factors will cause different requirements for optimal whole blood levels of cyclosporine. The reference ranges below are general guidelines and apply to trough specimens drawn just prior to a.m. dose.

Minimum Volume: 0.5 mL 

Stability: Room temperature: 24 hours
Refrigerated: 7 days
Frozen: Unacceptable

Reference Range:

100 – 400 ng/mL
Toxic: >700 ng/mL

Organ Kidney (w/Everolimus)
Post Transplant (months)
up to 1                  100-200 ng/mL
2 – 3                       75 – 150 ng/mL
4 – 5                      50 – 100 ng/mL
6 – 12                      25 – 50 ng/mL

Heart
Up to 3                350 – 525
>=4                      145 – 350

Liver                     290 – 525

Update to rejection criteria and stability.

Rejection Criteria: Grossly hemolyzed, heat-treated, microbially contaminated or lipemic specimens, plasma

Stability: Room temperature: Unacceptable
Refrigerated: 7 days
Frozen: Undetermined

Update to stability and reference range.

Stability: Room temperature: 24 hours
Refrigerated: 7 days
Frozen: 14 days 

Reference Range:

3.0 – 8.0 ng/mL
Critical value >15 ng/mL

Organ             Combined therapy with             Trough Level

Kidney                      Cyclosporine                    3.0 – 8.0 ng/mL

Liver                           Tacrolimus                      3.0 – 8.0 ng/mL

Update to specimen requirements, stability, and reference range.

Minimum Volume: 0.5 mL 

Stability: Room temperature: 24 hours
Refrigerated: 7 days
Frozen: Unacceptable 

Reference Range:

5 – 20 ng/mL
Toxic: >26 ng/mL

Update to specimen requirements, alternate specimen, and stability.

Minimum Volume: 0.5 mL

Alternate Specimen: No alternate specimen listing. 

Stability: Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 14 days

Update to stability.

Stability: Room temperature: Undetermined
Refrigerated: 8 days
Frozen: Undetermined

Update to stability.

Stability: Room temperature: Undetermined
Refrigerated: 21 days
Frozen: Undetermined 

Update to specimen requirements, alternate specimen, and stability.

Minimum Volume: 0.5 mL 

Alternate Specimen: No alternate specimen listing. 

Stability: Room temperature: 24 hours
Refrigerated: 7 days
Frozen: 14 days

Update to specimen requirements, alternate specimen, and stability.

Minimum Volume: 0.5 mL

Alternate Specimen: No alternate specimen listing. 

Stability: Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 14 days

Update to rejection criteria and stability.

Rejection Criteria: Grossly hemolyzed, heat-treated, microbially contaminated or lipemic specimens, plasma

Stability: Room temperature: 8 hours
Refrigerated: 21 days
Frozen: Undetermined 

Update to specimen requirements and stability.

Specimen Preparation: Centrifuge, separate serum from cells and send 1.0 mL serum in a screw capped plastic vial.

Minimum Volume: 0.5 mL

Stability: Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 14 days

Update to stability.

Stability: Room temperature: 8 hours
Refrigerated: 48 hours
Frozen: Undetermined

Update to stability.

Stability: Room temperature: 8 hours
Refrigerated: 48 hours
Frozen: Undetermined 

Update to stability.

Stability: Room temperature: 8 hours
Refrigerated: 48 hours
Frozen: Undetermined 

Update to stability.

Stability: Room temperature: 8 hours
Refrigerated: 48 hours
Frozen: Undetermined 

Update to stability.

Stability: Room temperature: 8 hours
Refrigerated: 48 hours
Frozen: Undetermined 

Update to stability.

Stability: Room temperature: 8 hours
Refrigerated: 48 hours
Frozen: Undetermined 

Update to LOINC code.

Interface Map:

Update to specimen requirements, stability, and reference range.

Minimum Volume: 0.5 mL 

Stability: Room temperature: 24 hours
Refrigerated: 7 days
Frozen: 14 days 

Reference Range:

4 – 12 ng/mL

Toxic Level: >25 ng/mL

Kidney Transplant (with cyclosporine)

Post Transplant: NA

Trough Level: 4.0 – 12.0 ng/mL

Kidney Transplant

Post Transplant:

After cyclosporine withdrawal:

<12 months      Trough Level: 16.0 – 24.0 ng/mL

>12 month        Trough Level: 12.0 – 20.0 ng/mL

Update to rejection criteria and stability.

Rejection Criteria: Grossly hemolyzed, heat-treated, microbially contaminated or lipemic specimens, plasma

Stability: Room temperature: 8 hours
Refrigerated: 48 hours
Frozen: Undetermined 

Update to alternate specimen and stability.

Alternate Specimen: No alternate listing.

Stability: Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 14 days

Update to specimen requirements and rejection criteria.

Collect: Yellow ACD B 

Specimen Preparation: Send 1 full tube whole blood collected in an ACD solution B (yellow-top) tube.

Minimum Volume: 6.0 mL 

Rejection Criteria: Hemolyzed samples. Samples oversaturated with ACD solution, Yellow ACD A

Update to specimen requirements and alternate specimen.

Minimum Volume: 0.5 mL 

Alternate Specimen: No alternate specimen listing. 

Update to test name and methodology.

Test Name: Amphetamine, Urine, Clinical, LC/MS-MS Confirmation (Quantitative) 

Methodology: Liquid Chromatography/Tandem Mass Spectrometry

Update to reference range and New York approval.

New York DOH Approval Status: No

Reference Range:

Decision level: 40 ng/mL
Phenobarbital: 200 ng/mL

Update to test name and clinical information.

Test Name: Benzodiazepine, Urine, Clinical, LC/MS/MS, Confirmation (Quantitative)

Clinical Information: Alprazolam confirmed as alpha hydroxy alprazolam.
                                     Clonazepam confirmed as 7-amino clonazepam.
                                     Flurazapam confirmed as 2-hydroxy ethyl flurazepam.

Update to test name and methodology.

Test Name: Cocaine, Urine, Clinical, LC/MS-MS Confirmation (Quantitative) 

Methodology: Liquid Chromatography/Tandem Mass Spectrometry 

Update to test name, stability, and New York approval.

Test Name: Ethanol, Urine, Clinical, Confirmation (Qualitative) 

Stability: Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 30 days

New York DOH Approval Status: No

Update to test name and methodology.

Test Name: Methadone, Urine, Clinical, LC/MS-MS Confirmation (Quantitative)

Methodology: Liquid Chromatography/Tandem Mass Spectrometry 

Update to test name and test performed days.

Test Name: Opiate, Urine, Clinical, LC/MS-MS Confirmation (Quantitative) 

Performed Days: Monday-Friday 

Update to test name, specimen requirements, and methodology.

Test Name: Phencyclidine, Urine, Clinical, LC/MS-MS Confirmation (Quantitative) 

Specimen Preparation: Send 10.0 mL urine in a screw capped plastic urine container. 

Minimum Volume: 3.0 mL

Methodology: Liquid Chromatography/Tandem Mass Spectrometry

Update to test name.

Test Name: Propoxyphene, Urine, Clinical, GC/MS Confirmation (Quantitative) 

Update to performed days and New York approval.

New York DOH Approval Status: No

Performed Days: Monday – Friday

Update to test name and specimen requirements.

Test Name: 6-Acetylmorphine, Urine, Clinical, Quantitative 

Minimum Volume: 11.0 mL

Update to stability and performed days.

Stability: Room temperature: 8 hours
Refrigerated: 48 hours
Frozen: Undetermined

Performed Days: Monday – Friday

Update to stability and performed days.

Stability: Room temperature: 8 hours
Refrigerated: 48 hours
Frozen: Undetermined 

Performed Days: Sunday, Thursday

Update to specimen requirements and stability.

Minimum Volume: 2.0 mL

Stability:

Whole Blood:
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: Unacceptable

Plasma, Urine, Serum:
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 30 days