March 2024 WML Test Directory Update

**THIS IS A REACTIVATED TEST FROM WARDE THAT SOME CLIENTS MAY HAVE ALREADY BUILT.
IT IS THE SAME TEST AS THE CURRENT COVG, JUST WITHOUT THE AOE PROMPTS**

Updates to specimen requirements, alternate specimen, rejection criteria, and methodology

Specimen Preparation: After drawing specimen, place green sodium heparin tube in ice bath. Centrifuge for 20 minutes 1000 x G. The plasma must be free of red blood cells. Send 2.0 mL plasma frozen in a screw capped plastic vial. CRITICAL FROZEN.

Minimum Volume: 1.0 mL

Alternate Specimen: Lavender: EDTA

Rejection Criteria: Specimen received not frozen.

Methodology: Liquid Chromatography/Mass Spectrometry

Updates to specimen requirements and rejection criteria.

Specimen Preparation: Cryoglobulin: Draw 5.0 mL of blood into a prewarmed (37°C) red top tube. Allow blood to clot at 37°C. Centrifuge at 37°C or ambient temperature. Do not use a refrigerated centrifuge. Keep sample at 37°C until after separation of serum from red blood cells. Send 3.0 mL of serum in a screw capped plastic vial.

Cryofibrinogen: Draw blood into a prewarmed (37°C) light blue sodium citrate tube. Centrifuge at 37°C or ambient temperature. Do not use a refrigerated centrifuge. Send 2.0 mL of plasma in a screw capped plastic vial.

Minimum Volume: Cryofibrinogen: 1.0 mL; Cryoglobulin: 2.0 mL

Rejection Criteria: Cryoglobulin: Plasma; Serum separator tube (SST); Grossly hemolyzed or lipemic specimens.

Cryofibrinogen: Serum; Heparinized plasma; Grossly hemolyzed or lipemic specimens

Updates to specimen requirements and rejection criteria.

Specimen Preparation: Draw 5.0 mL of blood into a prewarmed (37°C) red top tube. Allow blood to clot at 37°C. Centrifuge at 37°C or ambient temperature. Do not use a refrigerated centrifuge. Keep sample at 37°C until after separation of serum from red blood cells. Send 3.0 mL of serum in a screw capped plastic vial.

Minimum Volume: 2.0 mL

Rejection Criteria: Plasma; Serum separator tube (SST); Grossly hemolyzed or lipemic specimens

Updates to specimen preparation and rejection criteria

Specimen Preparation: Draw blood into a prewarmed (37°C) light blue sodium citrate tube. Centrifuge at 37°C or ambient temperature. Do not use a refrigerated centrifuge. Send 2.0 mL of plasma in a screw capped plastic vial.

Rejection Criteria: Serum; Heparinized plasma; Grossly hemolyzed or lipemic specimens

Update to reference range

Reference Range:

14-3-3 GAMMA (CSF): <173 – 1999 AU/mL
For other result components please see report.

Updates to specimen requirements, alternate specimen, rejection criteria, stability, methodology, and reference range.

Specimen Preparation: Plasma should be separated in a refrigerated centrifuge within 30 minutes of collection and then frozen immediately at -20°C in a screw capped plastic vial. Send 2.0 mL plasma frozen in a plastic screw capped vial.

Minimum Volume: 1.0 mL

Alternate Specimen: Lavender EDTA

Rejection Criteria: Gross hemolysis

Stability:

Room temperature: 6 hours
Refrigerated: 6 hours
Frozen: 31 days

Methodology: Liquid Chromatography Mass Spectrometry

Reference Range:

<18 years: No reference range available
> or = 18 years: Supine: <16 pg/mL
Upright: <27 pg/mL

Update to stability

Stability: Refrigerated for 7 days unopened.

Update to transport temperature

Transport temperature: Refrigerated

Update to CPT4 code

CPT Code(s): 81382

Update to performing laboratory

Performing Laboratory: Quest SJC

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Performing Laboratory: Quest SJC

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Performing Laboratory: Quest SJC

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